Remoting exception: Object 'xxx.rem' has been disconnected or does not exist at the server-Collection of common programming errors

I am developing web chat integrated to site on ASP.NET (.NET 4.5) using SignalR(v1.1.0). Also chat connected to Jabber server using WCF-service. Sometimes I receive the next exception in external code:

Remoting exception:

Object ‘xxx.rem’ has been disconnected or does not exist at the server.

Full Stacktrace:

System.Runtime.Remoting.RemotingException was unhandled
  HResult=-2146233077
  Message=Object '/76fe3e3d_b7ca_4973_9cf3_9d84e6d4268a/9emtey6i64mqzcxou+wc1_5x_808.rem' has been disconnected or does not exist at the server.
  Source=WebDev.WebHost40
  StackTrace:
       at Microsoft.VisualStudio.WebHost.Connection.get_Connected()
       at Microsoft.VisualStudio.WebHost.Request.IsClientConnected()
       at System.Web.HttpResponse.get_IsClientConnected()
       at System.Web.HttpResponseWrapper.get_IsClientConnected()
       at Microsoft.Owin.Host.SystemWeb.OwinCallContext.CheckIsClientConnected(Object obj)
       at System.Threading.TimerQueueTimer.CallCallbackInContext(Object state)
       at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
       at System.Threading.TimerQueueTimer.CallCallback()
       at System.Threading.TimerQueueTimer.Fire()
       at System.Threading.TimerQueue.FireQueuedTimerCompletion(Object state)
       at System.Threading.QueueUserWorkItemCallback.System.Threading.IThreadPoolWorkItem.ExecuteWorkItem()
       at System.Threading.ThreadPoolWorkQueue.Dispatch()
       at System.Threading._ThreadPoolWaitCallback.PerformWaitCallback()
  InnerException: 

I noted that it happens when client try to connect to SignalR hub.

I did’not find useful information about it in SO and other resorces. I don’t know what is it and how it should be fixed. Could you explain it, please. Any information will be helpful.